According to reports, the aircraft was brought down by a guided missile in countryside near Huwaysis to the east of the war-torn city of Homs.
There have been no reports of casualties or fatalities.
ISIS claimed the responsibility for the helicopter downing via their Amaq News Agency.
They tweeted: "A Russian attack helicopter is destroyed by a guided missile near the Huwaysis area in the eastern countryside of Homs."
Russian aircraft have been operating in the area this week after ISIS jihadists attacked Syrian Arab Army positions near the al-Mahr oilfield to the east of Homs on Monday.
More than 12 Syrian soldiers were killed and several more injured in the offensive which only came to end when Russian jets targeted ISIS hideouts in the area.